Professionals
Background
Brugada syndrome (BrS) is an inherited arrhythmogenic disorder characterized by coved-type ST-segment elevation in the right precordial leads, associated with increased risk of sudden death. It is genetically and clinically heterogeneous, presenting typically in the fourth or fifth decade of life.
The prevalence of BrS in the pediatric population is low compared with the adult population. However, over the last 5-10 years there has been growing evidence in the literature of disease onset during childhood.
Most pediatric BrS cases are asymptomatic. However, there are a number of patients who become symptomatic with a variety of conduction abnormalities, including life threatening ventricular arrhythmias and sudden cardiac death. This early disease expression may be precipitated by diverse factors, including genetic substrates, hormonal shifts, and unidentified environmental triggers.
Purpose and Significance of
the Pediatric Brugada Registry
The diagnosis and management of BrS among young patients remains challenging. Under the mentorship of Prof. Pedro Brugada, Cecilia Gonzalez Corcia has investigated the clinical characteristics, risk factors and prognosis of pediatric BrS. Based on a 30-year prospective database, initiated with the first pediatric BrS diagnosis, our team has elucidated the disease spectrum within young populations, identified prognostic markers for future arrhythmic events, and formulated clinical algorithms for high-risk patient identification. However, there are still many gaps in our understanding of the disease.
The aim of this project is to sustain an international pediatric BrS registry bringing together cases from different world regions, genetic characteristics and environmental backgrounds. We strongly believe that this objective can only be fulfilled with the support of many of our community members working in various parts of the world. By fostering dialogue, sharing insights, and pooling resources, we aspire to unravel the pathophysiological underpinnings of pediatric BrS and forge tailored approaches to patient care.
Our vision supports a collective collaboration within the medical and patient community, transcending geographical boundaries. Together, let us embark on this journey toward enhanced understanding, improved management, and, ultimately, brighter futures for children and families affected by BrS.
Download our Protocols
For more details
Handbook for Participating Centres:
"Pediatric Brugada Registry: An International Initiative for Risk Assessment and Management"
Optional Substudy on Biological Samples
(Saliva, blood and/or oral mucosa)
PARTICIPATING CENTRE
If you are a participating center involved in the care of children and adolescents with Brugada Syndrome (BrS), we invite you to join the registry. Patients can be enrolled by pediatric or adult electrophysiologists, pediatric or adult cardiologists, or nurse practitioners (or individuals with equivalent qualifications in different regions of the world). If you are interested in participating in the registry, please contact Dr Cecilia Gonzalez Corcia and her team who will be able to assist you with obtaining ethical approval and data sharing agreement (if required).
COORDINATING CENTRE
Please contact Dr Cecilia Gonzalez Corcia and her team
who will be able to assist you with obtaining ethical approval
and data sharing agreement (if required).
COORDINATING CENTRE
Please contact Dr Cecilia Gonzalez Corcia and her team who will be able to assist you with obtaining ethical approval and data sharing agreement (if required).